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History of Electromyography (EMG) and Nerve Conduction ...

Posted: (0 seconds ago) OBJECTIVE: To highlight the historical landmarks of EMG and NCS development by reviewing the major discoveries and publications of Bronk, Denny-Brown, Larrabee and Lambert. BACKGROUND: In 1771, Galvani Showed that electrical stimulation of muscular tissue produces contraction and force. This electrical response was not quantified until the development of improved recording equipment including ...

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Henry R. Viets, MD, and the History of Myasthenia Gravis ...

Posted: (0 seconds ago) Henry R. Viets (1890–1969) was both a noted neurologist and medical historian. While at Harvard Medical School, from which he graduated in 1916, he attracted the attention of Harvey Cushing who directed Viets into these disciplines. Cushing arranged for Viets to take a fellowship in Oxford in the year after his graduation. With Cushing's recommendation, he lived with Sir William and Lady ...

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A brief history of “Alzheimer disease” | Neurology

Posted: (0 seconds ago) The field of Alzheimer disease (AD) has a nosologic problem: The diagnostic label “Alzheimer disease” has several distinctive meanings. The term probable AD was introduced in 1984 to designate a clinically diagnosed acquired and progressive amnestic dementia for which there was no evidence for another etiology. Probable AD represented a clinicopathologic entity that assumed a specific and ...

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An 8,000-year History of Use and Abuse of Opium and ...

Posted: (0 seconds ago) Objective: To study the roots of opioid use. Background: The recent declaration of opioid-abuse crisis in the US, with 33,091 deaths in 2015 from overdosing, warrants cross-sectional and longitudinal surveys. Design/Methods: Analyzing published information. Results: 8000 year-old hardened Sumerian clay-tablets are the earliest prescriptions of opium. Ancient Greeks, Indians, Chinese, Egyptians ...

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Natural history of ALS | Neurology

Posted: (0 seconds ago) ALS is a disease that may have a preclinical and a clinical phase (see Appendix 1 Table 1). The low frequency of ALS suggests an inherent susceptibility in patients who are destined to develop the disease at a particular point in life subsequent to a possible initiating event. [1] View this table: Table 1. Appendix 1: Pathogenetic aspects of ALS. Neuropathological, neurophysiological, and ...

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Paul Broca and the history of aphasia | Neurology

Posted: (0 seconds ago) Paul Broca is one of the founding fathers of aphasiology. Broca aphasia, now a well-defined clinical entity, has been a focus in the study of acquired language disorders for over a century. It was the first syndrome of aphasia to be correlated with a specific focal brain lesion. Broca contributed a fresh outlook and a reasonable methodology to the study of aphasia.

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History of levodopa and dopamine agonists in Parkinson's ...

Posted: (0 seconds ago) Striatal dopamine deficiency in Parkinson's disease (PD), first described in 1960, was a key event that led to the era of levodopa therapy. In 1961, levodopa was first tried in PD patients, but throughout most of the 1960s the results were inconsistent. In 1967, questions about the effectiveness of levodopa in PD were finally set aside when Cotzias and colleagues reported dramatic improvement ...

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Insights into the natural history of spontaneous ...

Posted: (0 seconds ago) Objective To assess the pathophysiologic changes in patients with spontaneous intracranial hypotension (SIH) based on measures of CSF dynamics, and on the duration of symptoms, in a retrospective case-controlled study. Methods We included consecutive patients investigated for SIH at our department from January 2012 to February 2018. CSF leak was considered confirmed if extrathecal contrast ...

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The natural history of Parkinson's disease | Neurology

Posted: (0 seconds ago) In contrast, dopaminergic substitution undoubtedly has had a major impact on the natural history of PD, resulting in a reduction of the mortality ratio from about 3.0 to 1.5. This benefit has been noted particularly in patients in whom levodopa therapy was started early.

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The history of reflex hammers | Neurology

Posted: (0 seconds ago) Following the simultaneous description of muscle stretch reflexes by Heinrich Erb and Carl Westphal in 1875, neurologists used direct finger taps or chest percussion hammers to elicit these phenomena. Because of inadequacies of chest percussion hammers for eliciting muscle stretch reflexes, a variety of hammers were developed specifically for this purpose. In 1888, J. Madison Taylor, working ...

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Alice in Wonderland Syndrome:A History (P6.337) | Neurology

Posted: (0 seconds ago) OBJECTIVE: To trace the history of the Alice in Wonderland Syndrome BACKGROUND: John Todd first used the term (AWIS) to describe illusions of their body image or distortion external surroundings of patients with migraine or epilepsy. Todd coined AWIS based upon self-reported changes in body size and surroundings experienced by patients with migraine and Alice in Lewis Carroll's "Alice's ...

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Parental family history of dementia in relation to ...

Posted: (0 seconds ago) Objective: To determine the association of parental family history with risk of dementia by age at onset and sex of affected parent in a population-based cohort. Methods: From 2000 to 2002, we assessed parental history of dementia in participants without dementia of the Rotterdam Study. We investigated associations of parental history with risk of dementia until 2015, adjusting for ...

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The History of Aspirin: from Willow Bark to Thomas Edison ...

Posted: (0 seconds ago) OBJECTIVE: Examine the history of Aspirin in the 20th century. BACKGROUND: Acetylsalicylic acid (ASA), derived from willow bark, is a mainstay of neurologists for prevention of stroke. Commonplace today, the history of Aspirin portrays a fascinating story of drug discovery among historical events. DESIGN/METHODS: Pubmed review and texts: “Aspirin: The Remarkable Story of a Wonder Drug ...

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Dizziness as a sign of strokeAbout stroke | Neurology

Posted: (0 seconds ago) Dizziness is a common medical complaint. It “is the third most common medical symptom reported in general medical clinics and accounts for about 3%–5% of visits across care settings. In the United States, this translates to 10 million ambulatory visits per year because of dizziness, with roughly 25% of these visits to emergency departments. Many patients have transient or episodic symptoms ...

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A Prospective Study of Benign Fasciculation Syndrome (S45 ...

Posted: (0 seconds ago) Conclusions: Despite its benign natural history, BFS is a source of high morbidity for patients, both physically and psychologically. At two years, fasciculations resolved in only 5% of patients. Most still experienced subjective weakness, sensory symptoms, and cramps.

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A study on natural history of Duchenne muscular dystrophy ...

Posted: (0 seconds ago) Objective: To study natural history and genotype of DMD in selected cohort of DMD patients. Background: Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy affecting one in 3,500 live male births. There are no studies from India to describe natural history of DMD and role of geo-ethnic factors on natural history of motor milestone in DMD compared to Caucasian patients.

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Neuropathy in Navajo children | Neurology

Posted: (0 seconds ago) We describe a rare and apparently unique neuropathic syndrome among Navajo children living on the Navajo Reservation. Clinical features include sensorimotor neuropathy, corneal ulcerations, acral mutilation, poor weight gain, short stature, sexual infantilism, serious systemic infections, and liver derangement including Reye's syndrome-like episodes. Progressive CNS white matter lesions were ...

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Natural history of homonymous hemianopia | Neurology

Posted: (0 seconds ago) Objective: To describe the characteristics of spontaneous recovery of homonymous hemianopia (HH). Methods: The authors reviewed medical records of all patients with HH confirmed by formal visual field testing and seen in follow-up in their service between 1989 and 2004. Clinical characteristics, causes, neuroradiologic definition of lesion location, final outcome, and evolution of the visual ...

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